Read our latest paper!

A version 10 tutorial.

We just published a brief description of the new features in version 10 with a short tutorial on how to construct a classic PBPK model from the literature. Download and read the paper for free from here.

Berkeley Madonna version 10

Faster calculations, larger models, ... 64 bit.

Modeling made even easier

Version 10 is 2-5 times faster than previous versions, and it can handle large memory-intensive models. It's compatible with the latest Apple OS (Catalina & Big Sur) as well as current and planned Windows operating systems. 10 is a free upgrade for all version 9 users. For more details, click here.

Version 10 runs on the latest Apple M1/M2 chips

Compatible with macOS Catalina and later

A different way to model

Berkeley Madonna is an incredibly fast, general purpose differential equations solver. Its graphical interface provides an intuitive platform for constructing complex mathematical models with ease using symbols rather than writing equations. The software provides a suite of graphical tools for plotting your results. 

Features

Intuitive interface

Select various icons from the toolbar to quickly build models, while the equations are written automatically. Clicking run instantly solves the equations and plots the results.

Excellent visualization

Results are automatically graphed, and the user can create sliders to quickly explore the influence of changing parameters. Additional tools such as parameter plot and the fast Fourier transform button provide additional graphical insight.

Fast execution & more

Choose from many integration schemes to solve ODEs, difference equations, and discrete simulations. Easily extract parameter estimates from data with the curve fitting interface, and plot results for a sweep of parameter values with the batch runs  -  just a few of Berkeley Madonna's many features. 

Cellular pH regulation

The Machen lab at UC Berkeley uses Berkeley Madonna to unravel how cellular compartments maintain distinct pH values.

Exploring Mars

Scientists at the European Space Agency use Berkeley Madonna to help predict the battery performance of the Mars Express spacecraft.

Viral replication

The Weinberger lab at UCSF & the Gladstone Institute's Center for Cell Circuitry is using Berkeley Madonna to explore the nature of gene expression during HIV infection.

Conservation efforts

Researchers at Conservation International use Berkeley Madonna to help protect green sea turtles.